Combinations of alpha-2-delta ligands and...

Details Combinations of alpha-2-delta ligands and... Combinations of alpha-2-delta ligands and...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/196 (2006.01) A61K 31/197 (2006.01) A61K 31/27 (2006.01) A61K 31/407 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/473 (2006.01) A61K 31/55 (2006.01) A61K 31/662 (2006.01)

Patent

CA 2539377

The instant invention relates to a combination of an alpha-2-delta ligand and an AChE inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. Particularly preferred AChE inhibitors are donepezil (Aricept®), tacrine (cognex®), rivastigmine (Exelon®), physostgmine (Synapton®), galantamine (Reminyl), metrifonate (Promem), neostigmine (Prostigmin) and icopezil.

L'invention concerne une association d'un ligand alpha-2-delta et d'un inhibiteur de l'AChE à usage thérapeutique, notamment pour le traitement de la douleur, en particulier la douleur neuropathique. Les ligands alpha-2-delta particulièrement préférés sont la gabapentine and prégabaline. Les inhibiteurs de l'AChE particulièrement préférés sont le donépézil (Aricept®), la tacrine (cognex®), la rivastigmine (Exelon®), la physostgmine (Synapton®), la galantamine (Reminyl), le métrifonate (Promem), la néostigmine (Prostigmin) et l'icopézil.

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