Combinations of an ace inhibitor, a calcium channel blocker...

A - Human Necessities – 61 – K

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Details

A61K 31/55 (2006.01) A61K 31/4422 (2006.01) A61K 31/455 (2006.01) A61K 31/549 (2006.01)

Patent

CA 2482348

The present invention relates to a method of treatment of a condition or disease selected from the group consisting of hypertension, left ventricular dysfunction and hypertrophic cardiomyopathy, diabetic cardiac myopahty, supraventricular and ventricular arrhythmias, atrial fibrillation, atrial flutter, detrimental vascular remodeling, myocardial infarction and its sequelae, antheroscleorosis, angina (whether unstable or stable), renal insufficiency (diabetic and non-diabetic), heart failure, angina pectoris, diabetes, secondary aldosteronism, primary and secondary pulmonary hypertension, renal failure conditions, such as diabetic nephropathy, glomerulonephritis, scleroderma, glomecular sclerosis, proteinuria of primary renal disease,and also renal vascular hypertension, diabetic retinophathy, the management of other vascular disorders, such as migraine, peripheral vascular disease, Raynaud~s disease, luminal hyperplasia, endothelial dysfunction, cognitive dysfunction( such as Alzheimer's), glaucoma and stroke, comprising administering, to a mammal in need thereof, a therapeutically effective amount of a combination comprising (i) an ACE inhibitor, (ii) a calcium channel blocker (CCB), and (iii) a diuretic.

La présente invention concerne une méthode de traitement d'un état pathologique ou d'une maladie sélectionnés dans le groupe comprenant l'hypertension, le dysfonctionnement ventriculaire gauche et la cardiomyopathie hypertrophique, la myopathie cardiaque diabétique, les arythmies supraventriculaire et ventriculaire, la fibrillation auriculaire, le flutter auriculaire, le remodelage vasculaire préjudiciable, l'infarctus du myocarde et ses séquelles, l'athérosclérose, l'angine (instable ou stable), l'insuffisance rénale (diabétique et non diabétique), l'insuffisance cardiaque, l'angine de poitrine, le diabète, l'aldostéronisme secondaire, l'hypertension pulmonaire primaire et secondaire, les états d'insuffisance rénale, tels que la néphropathie diabétique, la glomérulonéphrite, la sclérodermie, la sclérose glomérulaire, la protéinurie de la maladie rénale primaire, ainsi que l'hypertension vasculaire rénale, la rétinopathie diabétique, le traitement d'autres troubles vasculaires, tels que la migraine, la maladie vasculaire périphérique, la maladie de Raynaud, l'hyperplasie luminale, le dysfonctionnement endothélial, le dysfonctionnement cognitif (tel que la maladie d'Alzheimer), le glaucome et l'accident vasculaire cérébral. Ladite méthode consiste à administrer, à un mammifère nécessitant un tel traitement, une quantité thérapeutiquement efficace d'une combinaison comprenant (i) un inhibiteur ACE, (ii) un inhibiteur calcique (CCB), et (iii) un diurétique.

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