Combinations of an anti-her2 antibody-drug conjugate and...

Details Combinations of an anti-her2 antibody-drug conjugate and... Combinations of an anti-her2 antibody-drug conjugate and...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/337 (2006.01) A61K 31/416 (2006.01) A61K 31/513 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61K 31/555 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2716592

Combinations of the antibody-drug conjugate trastuzumab-MCC-DM1 and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting tumor cell growth, and for treating disorders such as cancer mediated by HER2 and KDR (VEGFR receptor 1). Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Linvention concerne des combinaisons du conjugué anticorps-médicament trastuzumab-MCC-DM1 et dagents chimiothérapiques, y compris des stéréoisomères, des isomères géométriques, des tautomères, des solvates, des métabolites et des sels de qualité pharmaceutique de ceux-ci, qui sutilisent pour inhiber la croissance de cellules de tumeur, et pour traiter des troubles tels quun cancer à médiation par HER2 et KDR (récepteur 1 de VEGFR). Des procédés dutilisation de telles combinaisons pour un diagnostic, une prévention ou un traitement in vitro, in situ et in vivo de tels troubles dans des cellules de mammifère, ou daffections pathologiques associées, sont divulgués.

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