A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/727 (2006.01) C07K 16/24 (2006.01) C07K 16/36 (2006.01)
Patent
CA 2487420
The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF antibodies of the present invention are designed to bind to an epitope comprising the C-terminal macromolecular substrate binding region of TF. The invention also concerns methods of treating TF-VIIa related diseases or disorders comprising administering anti- TF antibodies alone or in combination with at least one additional anticoagulant and/or anti-platelet agent.
L'invention concerne des anticorps anti-TF possédant un pouvoir anticoagulant accru, ainsi que des procédés et des moyens servant à identifier, préparer et utiliser ces anticorps. Ces anticorps anti-TF sont conçus pour se fixer à un déterminant antigénique comprenant la zone de fixation de TF au substrat macromoléculaire à terminaison C. Elle concerne également des procédés de traitement de maladies ou de troubles apparentés à TF- VIIa, consistant à administrer ces anticorps anti-TF seuls ou combinés à au moins un agent supplémentaire anticoagulant et/ou anti-plaquettes.
Bunting Stuart
Kirchhofer Daniel
Refino Canio J.
Genentech Inc.
Smart & Biggar
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