A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/00 (2006.01) A61K 31/337 (2006.01) A61K 31/519 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 41/00 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2465314
An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
L'invention porte sur un anticorps ayant une interaction avec le récepteur DR5 ou DR4 humain et générant des effets agonistes ou antagonistes en aval du récepteur, cet anticorps permettant d'inhiber la prolifération cellulaire et l'apoptose. L'invention porte également sur des procédés de production et d'utilisation des anticorps, éventuellement en combinaison avec divers agents thérapeutiques, notamment dans le traitement de maladies relatives à l'apoptose et de la prolifération cellulaire anarchique.
Buchsbaum Donald J.
Ichikawa Kimihisa
Kimberly Robert P.
Koopman William J.
Lobuglio Albert F.
Gowling Lafleur Henderson Llp
The Uab Research Foundation
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