Combinations of epinastine, belladonna and pseudoephedrine...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/46 (2006.01) A61K 31/135 (2006.01) A61K 31/415 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2477751

The present invention relates to novel oral pharmaceutical compositions comprising as pharmaceutically active compounds a combination of an antihistaminic-effective amount of epinastine or a pharmaceutically acceptable salt thereof, an anticholinergic amount of Belladonna alkaloids (Belladonna) or a pharmaceutically acceptable salt thereof and of a decongestant-effective amount of pseudoephedrine or a pharmaceutically acceptable salt thereof. Optionally, the formulation may comprise methylephedrine (methylephrine) in a decongestant-effective amount or a pharmaceutically acceptable salt thereof. The formulation further comprises suitable pharmaceutically acceptable carriers or excipients. Another aspect of the present invention relates to methods for the preparation of these compositions and methods of using them in the treatment of allergic diseases and/or disorders. In particular the inventive composition is useful in the treatment of saisonal allergic rhinitis and saisonal allergic conjunctivitis.

La présente invention concerne de nouvelles compositions pharmaceutiques orales comprenant en tant que composés pharmaceutiquement actifs, une combinaison d'une quantité efficace antistaminique d'épinastine ou de son sel pharmaceutiquement acceptable, d'une quantité anticholinergique d'alcaloïdes de belladone (Belladone) ou de son sel pharmaceutiquement acceptable et d'une quantité décongestionnante efficace de pseudoéphédrine ou de son sel pharmaceutiquement acceptable. Eventuellement, ladite formulation peut comprendre de la méthyléphédrine (méthyléphrine) en une quantité décongestionnante efficace ou son sel pharmaceutiquement acceptable. Ladite formulation comprend également des supports ou des excipients pharmaceutiquement acceptables appropriés. Un autre aspect de la présente invention concerne des méthodes de préparation desdites compositions et des méthodes d'utilisation de ces dernières dans le traitement de maladies et/ou de troubles allergiques. Ladite nouvelle composition est notamment utile dans le traitement de la rhinite allergique saisonnière et de la conjonctivite allergique saisonnière.

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