Combinations of hmg coa reductase inhibitors and negatively...

Details Combinations of hmg coa reductase inhibitors and negatively... Combinations of hmg coa reductase inhibitors and negatively...

A - Human Necessities

61

K

A61K 31/683 (2006.01) A61K 31/40 (2006.01) A61K 31/505 (2006.01) A61K 47/20 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2554386

The present invention provides combinations of pharmaceutically active agents (i.e. statins and negatively charged phospholipids) for treating or preventing atherosclerosis or coronary artery disease (CAD) in mammals, and methods therefore. In particular, these combinations and methods find utility for achieving one or more of the following effects in a subject: (1) a reduction in plasma levels of low-density lipoprotein (LDL) cholesterol and very-low--density lipoprotein (VLDL) cholesterol; (2) an increase in plasma levels of high-density lipoprotein (HDL) cholesterol; and (3) a reduction in plasma levels of triglycerides.

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