Combinations of ketones and heterocyclic compounds,...

Details Combinations of ketones and heterocyclic compounds,... Combinations of ketones and heterocyclic compounds,...

A - Human Necessities

61

K

167/210

A61K 31/55 (2006.01)

Patent

CA 1166157

A618 COMBINATIONS OF KETONES AND HETEROCYCLIC COMPOUNDS, FORMULATIONS THEREOF, PREPARATION AND USE IN MEDICINE ABSTRACT Combinations comprising (i) a drowsiness - inducing benzodiazepine tranquilliser and (ii) a compound selected from m-chloro-?-t-butylamino- propiophenone, m-fluoro- ?-t- butylaminopropiophenone and the pharma- cologically and pharmaceutically acceptable acid addition salts thereof, pharmaceutical formulations comprising a said combination together with an acceptable carrier therefor, the preparation of such combinations and formulations, and the concomitant use in human medicine of such a benzo- diazepine compound and a said proplophenone or salt thereof. Concomitant administration of a said propiophenone or salt thereof prevents the functional impairment and drowsiness in man which follow the administratlon of such a benzodiazepine compound.

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