Combinations of oral medicaments bonded by a wrapping

Details Combinations of oral medicaments bonded by a wrapping Combinations of oral medicaments bonded by a wrapping

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 9/30 (2006.01)

Patent

CA 2713197

Oral pharmaceutical dosage form containing at least two medicaments, in which form the medicaments on the one hand are brought together in a leakproof and in-vivo water soluble wrapping and on the other hand are separated so that the active principle of the combined medicaments cannot come into contact with one another, at least one of the medicaments being selected from the following therapeutic classes: non-steroidal anti-inflammatory drug (NSAID), proton pump inhibitor (PPI), beta-blocker, statin, conversion enzyme inhibitor (CEI), biguanide, myorelaxant, calcium inhibitor, corticoid, antidepressant, benzodiazepine, non-atropine-like intestinal transit retarder, intestinal antibacterial, and the following therapeutic molecules: spironolactone, propranolol, clarithromycin, amoxycillin, low-dose acetylsalicylic acid, potassium, clopidogrel.

L'invention porte sur une forme posologique pharmaceutique orale contenant au moins deux médicaments, forme dans laquelle les médicaments, d'une part, sont réunis dans une enveloppe étanche et soluble dans l'eau in vivo et, d'autre part, sont séparés de telle sorte que les principes actifs des médicaments combinés ne peuvent pas venir en contact l'un avec l'autre, au moins l'un des médicaments étant choisi dans les classes thérapeutiques suivantes : un médicament anti-inflammatoire non stéroïdien (NSAID), un inhibiteur de la pompe à protons (PPI), un bêta-bloquant, la statine, un inhibiteur d'une enzyme de conversion (CEI), le biguanide, un myorelaxant, un inhibiteur du calcium, un corticoïde, un antidépresseur, la benzodiazépine, un retardateur de transit intestinal de type non-atropine, un antibactérien intestinal et les molécules thérapeutiques suivantes : la spironolactone, le propranolol, la clarithromycine, l'amoxycilline, l'acide acétylsalicylique à faible dose, le potassium et le clopidogrel.

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