A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4709 (2006.01) A61K 31/275 (2006.01) A61K 31/343 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61K 31/00 (2006.01)
Patent
CA 2489791
The present invention relates to a method of treating depression or anxiety in a mammal, including a human, by administering to the mammal a CNS-penetrant NK- 1 receptor antagonist (e.g., a substance P receptor antagonist) in combination with a PDE IV inhibitor. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier, a CNS-penetrant NK-1 receptor antagonist and a PDE IV inhibitor.
La présente invention concerne une méthode de traitement de la dépression ou de l'angoisse chez un mammifère, notamment chez l'homme, par administration au mammifère d'un antagoniste de récepteur de NK-1 pénétrant le SNC (par exemple un antagoniste du récepteur de la substance P) en combinaison avec un inhibiteur de PDE-IV. L'invention concerne également des compositions pharmaceutiques contenant un excipient pharmaceutiquement acceptable, un antagoniste du récepteur NK-1 pénétrant le SNC et un inhibiteur de PDE IV.
Lebel Lorraine Ann
Schmidt Christopher Joseph
Sobolov-Jaynes Susan Beth
Pfizer Products Inc.
Smart & Biggar
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