Combinations of peroxisome proliferator-activated receptor...

Details Combinations of peroxisome proliferator-activated receptor... Combinations of peroxisome proliferator-activated receptor...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/397 (2006.01) A61K 45/00 (2006.01)

Patent

CA 2434682

The present invention provides compositions, therapeutic combinations and methods including: (a) at least one peroxisome proliferator-activated receptor activator; and (b) at least one substituted azetidinone or substituted b- lactam sterol absorption inhibitor which can be useful for treating vascular conditions, diabetes, obesity and lowering plasma levels of sterols.

L'invention concerne des compositions, des combinaisons thérapeutiques et des procédés reposant sur l'utilisation: (a) d'au moins un activateur du récepteur activé par le proliférateur de péroxysome; et (b) d'au moins un inhibiteur d'absorption des stérols d'azétidinone ou de bêta-lactamine à substitution. Ces compositions, combinaisons thérapeutiques et procédés peuvent être utiles pour le traitement des troubles vasculaires, du diabète ou de l'obésité et pour la réduction du degré de concentration plasmique des stérols.

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