Combinations of peroxisome proliferator-activated receptor...

Details Combinations of peroxisome proliferator-activated receptor... Combinations of peroxisome proliferator-activated receptor...

A - Human Necessities

61

K

A61K 31/397 (2006.01) A61K 45/06 (2006.01) A61K 47/22 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2562982

The present invention provides compositions, therapeutic combinations and methods including: (a) at least one peroxisome proliferator-activated receptor activator; and (b) at least one substituted azetidinone or substituted b- lactam sterol absorption inhibitor which can be useful for treating vascular conditions, diabetes, obesity and lowering plasma levels of sterols.

La présente invention porte sur des préparations, des combinaisons thérapeutiques et des méthodes dont : a) au moins un activateur du récepteur activé par le proliférateur du peroxisome et b) au moins un inhibiteur d'absorption des stérols contenant une azétidinone substituée ou une beta- lactame substituée. Ces inhibiteurs sont utiles pour traiter des maladies vasculaires, le diabète et l'obesité et pour abaisser la concentration plasmatique des stérols.

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