Combinations of phosphoinositide 3-kinase inhibitor...

A - Human Necessities – 61 – K

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A61K 31/505 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2699202

Combinations of P13K inhibitor compounds having Formulas (I) and (II) and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

La présente invention concerne des combinaisons de composés inhibiteurs de PI3K de formules (I) et (II) et des agents chimiothérapeutiques, comprenant des stéréoisomères, des isomères géométriques, des tautomères, des métabolites et des sels pharmaceutiquement acceptables de ceux-ci, utiles pour le traitement de troubles hyperproliférants tels que le cancer. L'invention concerne également des procédés d'utilisation de telles combinaisons pour le diagnostic in vitro, in situ, et in vivo, de prévention ou de traitement de tels troubles dans des cellules mammaliennes, ou de conditions pathologiques associées.

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