C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/18 (2006.01) A61K 31/00 (2006.01) A61K 45/06 (2006.01) A61K 49/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2246734
This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for screening antitumor therapeutic agents suitable for combination therapy with protein kinase C inhibitors capable of potentiating apoptosis in tumor cells. This invention further provides different combination therapies comprising the specific protein kinase C inhibitors and the antitumor therapeutic agents.
L'invention concerne des méthodes de criblage rapide d'agents de modulation qui, quand ils sont combinés avec un agent thérapeutique antitumoral, augmentent l'apoptose de cellules tumorales. Elle concerne également des méthodes de criblage rapide d'agents thérapeutiques antitumoraux convenant à une thérapie associant ceux-ci avec des inhibiteurs de la protéine kinase C, pour augmenter l'apoptose de cellules tumorales, ainsi que des thérapies associant des inhibiteurs spécifiques de la protéine kinase C et les agents thérapeutiques antitumoraux.
Albino Anthony P.
Schwartz Gary K.
Gowling Lafleur Henderson Llp
Sloan-Kettering Institute For Cancer Research
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