A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4164 (2006.01) A61K 31/4184 (2006.01) A61K 31/4188 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2544573
The present invention provides a method for the treatment of neuronal disorders, in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of at least one QC-inhibitor (glutaminyl cyclase inhibitor), optionally in combination with at least one agent, selected from the group consisting of PEP-inhibitors, inhibitors of IDP IV/DP IV-~like enzymes, NPY-receptor ligands, NPY agonists, NPY antagonists, ACE-inhibitors, PIMT enhancers, inhibitors of beta secretases, inhibitors of gamma secretases and inhibitors of neutral endopeptidase, to a mammal in need thereof.
La présente invention concerne une méthode de traitement de troubles neuronaux chez un mammifère tel qu'un sujet humain, laquelle méthode consiste à administrer une dose efficace, non toxique et pharmaceutiquement acceptable d'au moins un inhibiteur de QC, facultativement en combinaison avec au moins un agent choisi dans le groupe contenant des inhibiteurs de PEP, des inhibiteurs de DP IV/d'enzymes de type DP IV, des ligands du récepteur NPY, des agonistes de NPY; des antagonistes de NPY, des inhibiteurs ACE, des activateurs PIMT, des inhibiteurs de bêta-secrétases, des inhibiteurs de gamma-secrétases ainsi que des inhibiteurs d'endopeptidase neutre, à un mammifère la nécessitant.
Demuth Hans-Ulrich
Niestroj Andre Johannes
Rossner Steffen
Schilling Stephan
Schulz Ingo
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Probiodrug Ag
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