Combinatorial 1,4-benzodiazepin-2,5-dione library

Details Combinatorial 1,4-benzodiazepin-2,5-dione library Combinatorial 1,4-benzodiazepin-2,5-dione library

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07D 243/14 (2006.01) C07D 243/24 (2006.01)

Patent

CA 2225914

A method has now been found of synthesizing a combinatorial library of 1,4- benzodiazepin-2,5-diones on solid supports via an aza-Wittig ring closure, said compounds optionally encoded with tags, and to the use of this library in assays to discover biologically active compounds, and, optionally, to cleave 1,4-benzodiazepin-2,5-diones therefrom.

La présente invention concerne un procédé nouveau permettant de synthétiser une banque combinatoire de 1,4-benzodiazépine-2,5-diones sur des supports solides par l'intermédiaire de la fermeture d'un cycle d'aza-Wittig. Les composés en question peuvent, le cas échéant, être encodés avec des étiquettes. L'invention concerne également l'utilisation de cette banque dans des analyses pour découvrir des composés actifs dans le domaine biologique et, en option, en séparer les 1,4-benzodiazépine-2,5-diones.

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