Combinatorial dihydrobenzopyran library

Details Combinatorial dihydrobenzopyran library Combinatorial dihydrobenzopyran library

C - Chemistry, Metallurgy

07

D

C07D 491/107 (2006.01) A61K 31/33 (2006.01) C07C 201/12 (2006.01) C07C 205/59 (2006.01) C07D 311/08 (2006.01) C07D 311/22 (2006.01) C07D 311/68 (2006.01) C07D 311/96 (2006.01) C07D 491/10 (2006.01) C07D 491/20 (2006.01) C07D 493/10 (2006.01) C07D 495/10 (2006.01) C07D 497/10 (2006.01) C12Q 1/527 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2189634

Combinatorial libraries are disclosed which are represented by the Formula (I): (T'-L)q- S -C(O)-L'-II' wherein S is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of formula (II) which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptor, .sigma.- opiate receptors, and K+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.

L'invention a pour objet des bibliothèques combinatoires représentées par la formule (I): (T'-L)¿q?- ?S¿ -C(O)-L'-II', dans laquelle ?S¿ est un support solide, T'-L est un résidu d'identifiant et -L'-II' est un résidu de liant. Ces bibliothèques contiennent des dihydrobenzopyranes selon la formule (II), qui interagissent (en tant qu'agonistes ou antagonistes) avec des récepteurs .alpha.-adrénergiques, des récepteurs de la dopamine, des récepteurs de .sigma.-opiacés et les voies de K?+¿, et qui inhibent les isozymes de l'anhydrase carbonique. Ils sont utiles pour le traitement d'affections oculaires telles que le glaucome.

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