Combinatorial dihydrobenzopyran library

Details Combinatorial dihydrobenzopyran library Combinatorial dihydrobenzopyran library

C - Chemistry, Metallurgy

07

D

C07D 311/22 (2006.01) C07C 201/12 (2006.01) C07C 205/59 (2006.01) C07C 233/01 (2006.01) C07D 311/96 (2006.01) C07D 491/107 (2006.01) C07D 493/10 (2006.01) C07D 493/20 (2006.01) C07D 495/10 (2006.01) C07D 495/20 (2006.01) C07D 497/10 (2006.01) C07D 497/20 (2006.01) C12Q 1/527 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2236045

Combinatorial libraries are disclosed which are represented by Formula (I), wherein S is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of Formula (II) which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptors, .sigma.-opiate receptors, and K+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.

La présente invention concerne des banques combinatoires représentées par la formule (I). Dans cette formule, S représente un support solide; T'-L représente un reste identifiant et -L'-II' représente un reste ligand/segment de liaison. Ces banques contiennent des dihydrobenzopyranes représentés par la formule (II), lesquels sont en interaction (comme agonistes ou antagonistes) avec des récepteurs .alpha. adrénergiques, des récepteurs de la dopamine, des récepteurs du .sigma.-opiate et des canaux K?+¿, et constituent des inhibiteurs des isozymes d'anhydrase carbonique. Ces banques conviennent particulièrement dans le traitement d'affections oculaires telles que le glaucome.

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