Combinatorial engineering

Details Combinatorial engineering Combinatorial engineering

C - Chemistry, Metallurgy

12

N

C12N 15/67 (2006.01) C12N 15/113 (2010.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2761277

The invention concerns the field of cell culture technology. It concerns production host cell lines with increased expression of ribosomal RNA (rRNA) achieved through introduction of nucleic acids encoding UBF or reducing expression of NoRC proteins, especially of TIP-5. Those cell lines have improved secretion and growth characteristics in comparison to control cell lines. The invention further concerns a method of producing proteins using the cells generated by the described method.

La présente concerne le domaine de la technologie de culture cellulaire ainsi que la production de lignées de cellules hôtes présentant une expression accrue d'ARN ribosomique (ARNr) obtenue par introduction d'acides nucléiques codant UBF ou réduction de l'expression des protéines NoRC, plus particulièrement de TIP-5. Ces lignées cellulaires présentent des caractéristiques de sécrétion et de croissance améliorées comparativement aux lignées cellulaires témoins. Cette invention concerne également un procédé de production de protéines dans lequel on utilise les cellules produites au moyen dudit procédé présenté.

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