Combinatorial libraries of monomer domains

Details Combinatorial libraries of monomer domains Combinatorial libraries of monomer domains

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 47/42 (2006.01) C08F 2/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2504670

Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

L'invention concerne des méthodes permettant d'identifier des domaines de monomère discrets et des immuno-domaines possédant une propriété désirée. Elle concerne des méthodes de production de multimères à partir d'un ou de plusieurs domaines de monomère discrets choisis, ainsi que des méthodes d'identification de multimères possédant une propriété désirée. L'invention concerne également des systèmes de présentation, qui présentent les domaines de monomère et/ou les immuno-domaines discrets, des domaines de monomère et/ou des immuno-domaines choisis, des multimères et/ou des multimères choisis, afin de permettre leur sélection. L'invention concerne en outre des compositions, de bibliothèques et des cellules exprimant un ou plusieurs éléments de la bibliothèque, ainsi que des trousses et des systèmes intégrés.

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