Combinatorial nucleobase oligomers comprising universal base...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) B01J 19/00 (2006.01) C07H 21/04 (2006.01) C07K 1/04 (2006.01) C07K 14/00 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2528958

The invention relates to insulating combinatorial nucleobase oligomers that comprise universal base analogs, where the oligomers are formed by the ligation of two or more oligomer "blocks" via a covalent linkage. Universal bases may serve to insulate specifically binding nucleobases from the effects of the covalent linker region joining two oligomer blocks together, so that the universal bases at least partially negate the Tm penalty caused by the covalent linkage, effective to reduce the required minimal length of the oligomer blocks and the combinatorial oligomer. The resulting insulating nucleobase combinatorial oligomers find use in any hybridization-based application, including use as probes and primers. The combinatorial oligomers of the present invention provide advantages over existing combinatorial oligomer systems currently known in the art.

Cette invention se rapporte à des oligomères de nucléobases combinatoires isolants qui contiennent des analogues de bases universelles et qui sont formés par la ligature d'au moins deux blocs oligomères via une liaison covalente. Les bases universelles peuvent servir à isoler des nucléobases spécifiquement liantes des effets de la zone de liaison covalente joignant deux blocs oligomères ensemble, afin que les bases universelles effacent au moins partiellement la pénalité T¿m? causée par la liaison covalente, ce qui a pour effet de réduire la longueur minimale requise des blocs oligomères et de l'oligomère combinatoire. Les oligomères combinatoires de nucléobases isolants qui en résultent trouvent une utilisation dans toute application d'hybridation, y compris comme sondes et amorces. Ces oligomères combinatoires présentent des avantages par rapport aux systèmes d'oligomères combinatoires existants de l'état actuel de la technique.

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