Combinatorial polyketide libraries produced using a modular...

Details Combinatorial polyketide libraries produced using a modular... Combinatorial polyketide libraries produced using a modular...

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C07D 309/00 (2006.01) C07D 313/00 (2006.01) C07D 313/04 (2006.01) C07D 323/00 (2006.01) C07D 493/10 (2006.01) C07H 17/08 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 15/76 (2006.01) C12P 17/08 (2006.01) C12P 19/46 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2288030

Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.

Bibliothèques combinatoires de polycétides qui peuvent être obtenues par manipulation appropriée d'un groupe de gènes modulaire hôte de polycétide synthase tel que celui qui code la polycétide synthase pour l'érythromycine. Ladite bibliothèque est utile en tant que source de composés à activité pharmacologique. De plus, de nouveaux polycétides et antibiotiques sont préparés selon ce procédé.

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