Combinatorial polypeptide antigens

Details Combinatorial polypeptide antigens Combinatorial polypeptide antigens

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 39/00 (2006.01) C07K 4/02 (2006.01) C07K 4/04 (2006.01) C07K 14/15 (2006.01) C07K 14/16 (2006.01)

Patent

CA 2137912

This invention pertains to a set of polypeptide antigens having amino acid sequences derived from amino acid sequences of a population of variants of a protein, or a portion thereof, and to methods of producing the set of polypeptide antigens. In general, the method comprises (i) selecting a protein, or a portion thereof, which exhibits a population of N variants, represented by the formula A1A2A3...A n-2A n-1A n, where A n is an amino acid occurring at amino acid position n of the protein, or portion thereof; (ii) determining the number of times O n aa each type of amino acid occurs at each amino acid position n in the N variants; (iii) calculating the frequency of occurrence (O n aa/N)n of each type of amino acid at each amino acid position n in the N variants; and (iv) generating a set of polypeptide antigens having amino acid sequences represented substantially by the formula A'1A'2A'3...A'n-2A'n-1A'n, where A'n is defined as an amino acid type which occurs at greater than a selected frequency at the corresponding amino acid position in the N variants.

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