Combinatorial selection of phosphorothioate aptamers for...

Details Combinatorial selection of phosphorothioate aptamers for... Combinatorial selection of phosphorothioate aptamers for...

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A01N 43/04 (2006.01) A61K 31/70 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2572446

The present invention includes the selection and isolation of thioaptamers that target the signaling protein TGF-~ l, compositions of such thioaptamers and the use of such thioaptamers to either block or enhance signal transduction of the TGF-~l protein and thus function as, e.g., immunomodulatory agents. Thioaptamers may also be targeted alone or in combination with other thioaptamers against the ligand, the receptors, the ligand trap protein(s) and/or the co-receptors to modulate TGF-~ signaling pathway.

La présente invention comprend la sélection et la séparation de thioaptamères qui ciblent la protéine de signalisation TGF-ß l, des compositions de tels thioaptamères et l'utilisation de tels thioaptamères soit pour bloquer soit pour accroître la transduction de signal de la protéine TGF-ßl et donc pour servir, par exemple, d'agents immunomodulateurs. Les thioaptamères peuvent également être ciblés seuls ou en association avec d'autres thioaptamères vis-à-vis du ligand, des récepteurs, de la ou des protéines piégeant le ligand et/ou des co-récepteurs pour moduler la voie de signalisation du TGF-ß.

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