Combinatorial synthesis of libraries of macrocyclic...

Details Combinatorial synthesis of libraries of macrocyclic... Combinatorial synthesis of libraries of macrocyclic...

C - Chemistry, Metallurgy

07

K

C07K 5/12 (2006.01) C07B 61/00 (2006.01) C07K 1/04 (2006.01) C07K 5/083 (2006.01) C07K 5/09 (2006.01) C07K 5/093 (2006.01) C07K 7/54 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2284459

A library of macrocyclic compounds of the formula (I) (see formula I) - where part (A) is a (see formula II) bivalent radical, a -(CH2)y- bivalent radical or a covalent bond; - where part(B) is a (see formula III) bivalent radical, a -(CH2)z- bivalent radical, or a covalent bond; - where part (C) is a (see formula IV) bivalent radical, a -(CH2)t- bivalent radical, or a covalent bonds and - where part (T) is a - Y - L - Z - radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for their preparation of these compounds in a combinatorial manner, is also disclosed.

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