C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 17/02 (2006.01) A61P 35/00 (2006.01) C07K 16/22 (2006.01)
Patent
CA 2646611
The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them.
La présente invention concerne l'utilisation d'antagonistes VEGF et d'antagonistes alpha5bêta1 pour traiter le cancer et inhiber l'angiogenèse et/ou la perméabilité vasculaire, notamment pour inhiber l'angiogenèse anormale dans des maladies. La présente invention a aussi pour objet l'utilisation d'un agoniste VEGFR et d'un agoniste alpha5bêta1 de façon à favoriser l'angiogenèse et la perméabilité vasculaire, ainsi que des nouveaux anticorps anti-alpha5bêta1, des compositions et des kits les comprenant et leurs méthodes de fabrication et d'utilisation.
Chuntharapai Anan
Plowman Greg
Tessier-Lavigne Marc
Wu Yan
Ye Weilan
Genentech Inc.
Smart & Biggar
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