A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2663521
Described are uses of an agent that reduces B7-H1 interaction with PD-I, and particularly monoclonal antibodies that bind to B7-H1 and interfere with B7-H1 interaction with PD-I in combination with a vaccine to provide synergistic effects. The application provides methods of treatment and vaccination based on the combination of these compounds on T cell responses.
La présente invention concerne des utilisations d'un agent qui réduit l'interaction de B7-H1 avec PD-I, et en particulier des anticorps monoclonaux qui se lient à des B7-H1 et interfèrent avec l'interaction de B7-H1 avec PD-I, en combinaison avec un vaccin, pour fournir des effets de synergie. L'application concerne également des procédés de traitement et de vaccination basés sur la combinaison de ces composés selon les réponses des cellules T.
Chen Lieping
Cox Andrea
Drake Charles
Pardoll Drew
Gowling Lafleur Henderson Llp
The Johns Hopkins University
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