A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 48/00 (2006.01) A61K 51/08 (2006.01) A61K 51/12 (2006.01)
Patent
CA 2312778
A method of antitumor therapy is described in which administration of a chemotherapeutic drug, encapsulated in liposomes, is supplemented by administration of an immunostimulating cytokine. The cytokine is preferably also encapsulated in liposomes. In tumor models for lung and colon carcinomas, this method produced a significantly greater therapeutic effect, as evidenced by survival rate and tumor size, than a combination of the effects produced by the free or liposome-encapsulated components administered individually.
On décrit un procédé de traitement anticancéreux dans lequel l'administration de médicaments chimiothérapeutiques encapsulés dans des liposomes est remplacée par l'administration d'une cytokine immunostimulant, de préférence également encapsulée dans des liposomes. Ce procédé a un effet thérapeutique sensiblement plus efficace dans des formes de cancer du poumon ou du côlon (ainsi que l'attestent les taux de survie et la taille des tumeurs) que les effets combinés de médicaments contenant ou non des substances encapsulées dans des liposomes administrés séparément.
Barenholz Yechezkel
Gabizon Alberto A.
Kedar Eliezer
Gowling Lafleur Henderson Llp
Hadasit Medical Research Services And Development Ltd.
Yissum Research Development Company Of The Hebrew University Of
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