Combined compositions and methods for tumor vasculature...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 35/00 (2006.01) A61K 38/01 (2006.01) A61K 38/19 (2006.01) A61K 38/36 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/36 (2006.01) C07K 16/44 (2006.01)

Patent

CA 2461905

Disclosed are various defined combinations of agents for use in improved anti- vascular therapies and coagulative tumor treatment. Particularly provided are combined treatment methods, and associated compositions, pharmaceuticals, medicaments, kits and uses, which together function surprisingly effectively in the treatment of vascularized tumors. The invention preferably involves a component or treatment step that enhances the effectiveness of therapy using targeted or non-targeted coagulants to cause tumor vasculature thrombosis.

L'invention concerne diverses combinaisons d~finies d'agents, destin~es ~ Útre utilis~es dans le cadre de th~rapies anti-vasculaires am~lior~es et d'un traitement am~lior~ de tumeurs par coagulation. L'invention se rapporte en particulier ~ des m~thodes de traitement combin~es, et ~ des compositions, des m~dicaments, des ~quipements et des techniques associ~s, qui, utilis~s conjointement, permettent de traiter avec une efficacit~ surprenante les tumeurs vascularis~es. L'invention concerne de pr~f~rence un composant ou une ~tape de traitement qui am~liore l'efficacit~ de la th~rapie, au moyen de coagulants cibl~s ou non cibl~s provoquant la thrombose du r~seau vasculaire tumoral.

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