Combined diffusion/osmotic pumping drug delivery system

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/36 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 9/30 (2006.01)

Patent

CA 2396258

A delivery device [(1) in Figure 1a] capable of delivering one or more active substances by diffusion through plural micropores in the membrane (4) or by osmotic pumping through one or more performed passageways (5) in the membrane is provided. The device (1) contains a centrally located expandable core (2) completely surrounded by an active substance containing layer (3), which is completely surrounded by the membrane (4). The device is capable of delivering insoluble, slightly soluble, sparingly soluble and very soluble active substances to an environment of use. The preferred delivery rate is zero order. The device can deliver an active substance for a period of about 12-24 hours.

L'invention concerne un système de distribution capable de distribuer au moins une substance active par diffusion à travers plusieurs micropores d'une membrane (4), ou par pompage osmotique dans au moins un passage préformé (5) dans ladite membrane. Le dispositif (1) contient un noyau extensible (2) placé centralement, complètement entouré par une couche (3) renfermant une substance active, elle-même complètement entourée par la membrane (4). Ce dispositif est capable de distribuer des substances actives insolubles, légèrement solubles, difficilement solubles, et très solubles à un environnement d'utilisation. La vitesse de distribution préférée est de l'ordre de zéro. Le dispositif peut distribuer une substance active pendant une durée d'environ 12-24 heures.

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