A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/129
A61K 39/295 (2006.01) A61K 39/116 (2006.01)
Patent
CA 1209036
COMBINED HAEMOPHILUS INFLUENZAE AND DIPHTHERIA, PERTUSSIS, TETANUS VACCINE ABSTRACT A vaccine for eliciting polyribosyl ribitol phosphate (PRP) antibody formation in a warm-blooded animal has been invented. The vaccine comprises the capsular polysaccharide PRP isolated and purified from Haemophilus influenzae type b combined with a diphtheria, Bordetella pertussis and tetanus (DPT) vaccine. A method of making a vaccine for eliciting polyribosylribitol phosphate (PRP) antibody formation in a warm-blooded animal has also been invented. The method of making comprises obtaining purified PRP; dissolving the PRP in phosphate buffered saline solution having a pH of about 7.0; sterile filtering the PRP solution; and combining the PRP solution with a diphtheria, B. pertussis and tetanus (DPT) vaccine. Finally, a method for inducing active immuniza- tion in a warm-blooded animal against systemic infection caused by the pathogen H. influenzae type b has been in- vented. The method of using comprises administering an immunogenic amount of a vaccine comprising the capsular polysaccharide polyribosyl ribitol phosphate (PRP) iso- lated and purified from H. influenzae type b combined with a diphtheria, B. pertussis and tetanus (DPT) vaccine.
416522
Kuo Joseph S.c.
American Cyanamid Company
Smart & Biggar
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