Combined meningococcal conjugates with common carrier protein

Details Combined meningococcal conjugates with common carrier protein Combined meningococcal conjugates with common carrier protein

A - Human Necessities

61

K

A61K 39/095 (2006.01) A61K 47/48 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2564366

Carrier-induced epitopic suppression is of particular concern where multiple conjugates with the same carrier protein are administered simultaneously. To avoid the suppression, the invention minimises the amount of unconjugated carrier protein in a vaccine. The invention provides a composition for immunising a patient against a disease caused by Neisseria meningitidis, wherein (1) the composition comprises conjugates for at least two of the four meningococcal serogroups A, C, W135 and Y, where at least two of the conjugates have a common carrier protein; and (2) the composition includes the common carrier in an unconjugated form at less than 10 µg/ml.

La suppression épitopique induite par un porteur pose particulièrement problème, lorsque plusieurs conjugués présentant la même protéine porteuse sont administrés simultanément. Pour éviter cette suppression, l'invention vise à réduire la quantité de protéines porteuses non conjuguées dans un vaccin. L'invention concerne une composition pour immuniser un patient contre une maladie provoquée par <i>Neisseria meningitidis</i>. (1) Cette composition comprend des conjugués pour au moins deux des quatre sérogroupes méningococciques A, C, W135 et Y, au moins deux de ces conjugués présentant une protéine porteuse commune; et (2) la composition comprend le porteur commun sous une forme non conjuguée à moins de 10 ?g/ml.

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