A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/135 (2006.01) A61K 31/355 (2006.01) A61K 31/4015 (2006.01) A61K 31/445 (2006.01) A61K 31/475 (2006.01) A61K 31/55 (2006.01) A61K 45/06 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2559493
The invention relates to a combined pharmaceutical composition for the inhibition of the decline of cognitive functions comprising as A) component (1R,2S,4R)-(-)-2-[N,N-(dimethylaminoethoxy)]-2-phenyl-1,7,7-trimethylbicyclo]- 2-phenyl-1.7.-trimethylbicyclo[2.2.1]heptane of the formula (I) or a pharmaceutically acceptable acid addition salt thereof and as B) component a nootropic, an inhibitor of the acetylcholinesterase enzyme and/or a further pharmaceutical active ingredient which exhibits a beneficial effect on the cognitive processes in admixture with suitable inert pharmaceutical carriers and/or auxiliary agents. The combined pharmaceutical composition according to the present invention can be particularly used for the treatment of Alzheimer disease or other diseases showing similar symptoms, diseases accompanied by malfunctions of intellectual abilities (e.g. mental decline in schizophrenia), mental decline in elderly (dementias in elderly), Korsakoff syndrome, Huntington syndrome, Parkinson syndrome or mental decline produced by alcoholism.
L'invention concerne une composition pharmaceutique combinée destinée à inhiber le déclin de fonctions cognitives, qui comprend comme composant A) (1R,2S,4R)-(-)-2-[N,N-(diméthylamino-éthoxy)]-2-phényl-1,7,7-triméthylbicyclo [2.2.1]heptane de la formule (I) ou un sel d'addition à un acide pharmaceutiquement acceptable de ce dernier et comme composant B) un nootropique, un inhibiteur de l'enzyme acétyl cholinestérase et/ou un autre ingrédient pharmaceutique actif présentant un effet bénéfique sur les processus cognitifs en mélange avec des excipients pharmaceutiques inertes et/ou des agents auxiliaires. La composition pharmaceutique combinée selon l'invention peut être utilisée en particulier dans le traitement de la maladie d'Alzheimer ou d'autres maladies présentant des symptômes similaires, de maladies accompagnées de dysfonctionnements de facultés intellectuelles (par exemple déclin mental en schizophrénie), de déclin mental chez les personnes âgées (démence chez les personnes âgées), le syndrome de Korsakoff, le syndrome de Huntington, le syndrome de Parkinson ou le déclin mental dû à l'alcoolisme.
Gacsalyi Istvan
Harsing Laszlo Gabor
Levay Gyoergy
Simig Gyula
Egis Gyogyszergyar Nyrt.
Fetherstonhaugh & Co.
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