Combined pharmaceutical preparation for treatment of type 2...

Details Combined pharmaceutical preparation for treatment of type 2... Combined pharmaceutical preparation for treatment of type 2...

A - Human Necessities

61

K

A61K 31/4035 (2006.01) A61K 31/133 (2006.01) A61K 45/00 (2006.01) A61P 3/10 (2006.01) C07D 209/44 (2006.01)

Patent

CA 2605302

A pharmaceutical preparation for controlling the condition of type 2 diabetes, the pharmaceutical preparation comprising the combination of mitiglinide or a pharmacologically acceptable salt or hydrate thereof and an .alpha.- glycosidase inhibitor (e.g., voglibose, acarbose); and a therapeutic method using the pharmaceutical preparation. The pharmaceutical preparation shows an extremely potent effect of decreasing the morning fasting blood glucose level, the postprandial blood glucose level and HbAlc in a patient with type 2 diabetes and can ameliorate glucose spike, insulin resistance and lipid metabolism.

L'invention concerne une préparation pharmaceutique pour contrôler l'état d'un diabétique de type 2, laquelle préparation contient une combinaison de mitiglinide ou d'un sel ou d'un hydrate pharmaceutiquement acceptable de celui-ci et d'un inhibiteur d'.alpha.-glycosidase (par exemple la voglibose, l'acarbose); et un procédé thérapeutique utilisant la préparation pharmaceutique. Cette préparation présente un effet extrêmement puissant pour réduire la glycémie à jeun le matin, la glycémie post-prandiale et l'HbAlc chez un patient atteint de diabète de type 2 et peut améliorer les pics de glucose, la résistance de l'insuline et le métabolisme lipidique.

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