Combined preparation for the treatment of cardiovascular...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/22 (2006.01) A61K 9/12 (2006.01) A61K 31/4184 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2663805

The present invention relates to a functional combination preparation comprising a dihydropyridine-based calcium channel blocker such as amlodipine and an ARB (Angiotensin-2 receptor blocker) such as losartan. In particular, the present invention relates to a chronotherapeutical combination pharmaceutical formulations with controlled-release for the prevention or treatment of cardiovascular disease, which is formulated in accordance with xenobiotics and chronotherapy for enabling the two drugs to be chronotherapeutically released, thereby improving the therapeutic activity as compared to the co-administration of each drug in the form of a single pill, while reducing side effects and maintaining the therapeutic activity as high as possible at the time of day when the risk of a complication of cardiovascular disease is highest.

La présente invention concerne une préparation combinée fonctionnelle contenant un inhibiteur calcique à base de dihydropyridine tel que de l'amlodipine et un ARB (inhibiteur des récepteurs de l'angiotensine II) tel que du losartan. L'invention se rapporte en particulier à des formulations pharmaceutiques combinées chronothérapeutiques à libération prolongée, destinées à prévenir ou à traiter les maladies cardio-vasculaires, qui sont préparées en accord avec la xénobiotique et la chronothérapie afin de permettre aux deux médicaments d'être libérés de manière chronothérapeutique, ce qui garantit une meilleure activité thérapeutique que lorsque les médicaments sont co-administrés sous la forme d'un comprimé unique, réduit en outre les effets secondaires et maintient l'activité thérapeutique à un niveau aussi élevé que possible au moment de la journée qui présente le plus haut risque de complications de la maladie cardio-vasculaire.

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