A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/64 (2006.01) A61K 31/549 (2006.01) A61P 7/10 (2006.01)
Patent
CA 2620647
The invention relates to pharmaceutical preparations which contain a combination of a thiazide diuretic and a low dose of a loop diuretic and which is particularly suitable for treating hypertension and heart failure. It is not only the natriuretic/diuretic effects which are increased due to said combination of thiazide diuretic and loop diuretic, but also the undesired secondary effects in relation to potassium and magnesium losses are also significantly reduced. As a result, the desired hypocalciuric effect of the thiazide is maintained despite the presence of the loop diuretic.
La présente invention concerne des préparations pharmaceutiques qui comprennent une combinaison d'un diurétique de thiazide avec un diurétique de boucle faiblement dosé, et qui conviennent particulièrement au traitement de l'hypertonie et de l'insuffisance cardiaque. Cette combinaison de diurétique de thiazide et de diurétique de boucle permet non seulement d'augmenter globalement l'effet natriurétique / diurétique, mais aussi de limiter de façon significative les effets secondaires indésirables en ce qui concerne les pertes en potassium et en magnésium. L'invention permet de conserver l'effet hypocalciurique souhaité du thiazide, malgré la présence du diurétique de boucle.
Knauf Heinrich
Mutschler Ernst
Borden Ladner Gervais Llp
Hexal Ag
Knauf Heinrich
LandOfFree
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