Combined therapy against tumors comprising substituted...

Details Combined therapy against tumors comprising substituted... Combined therapy against tumors comprising substituted...

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/00 (2006.01) A61K 31/335 (2006.01) A61K 31/40 (2006.01) A61K 31/475 (2006.01) A61K 31/505 (2006.01) A61K 31/565 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2411172

The present invention provides the combined use of acryloyl distamycin derivatives, in particular .alpha.-bromo- and .alpha.-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and an antineoplastic topoisomerase I or II inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.

Cette invention a trait à l'utilisation combinée, aux fins du traitement de tumeurs, de dérivés de distamycine acryloyle, notamment de dérivés de alpha -bromo et de alpha -chloro distamycine acryloyle correspondant à la formule (I), comme définie dans le descriptif, et d'un inhibiteur de la topoisomérase I ou II à action antinéoplasique. L'invention concerne également l'utilisation de ces combinaisons pour le traitement ou la prévention des métastases ou encore pour le traitement de tumeurs par inhibition de l'angiogenèse.

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