A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 31/335 (2006.01) A61K 31/40 (2006.01) A61K 31/475 (2006.01) A61K 31/505 (2006.01) A61K 31/565 (2006.01) A61K 31/7064 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2412054
The present invention provides the combined use of acryloyl distamycin derivatives, in particular .alpha.-bromo- and -.alpha.-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, antimicrotubule agents and/or an antimetabolites. Also provided is the use of the said combination in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
La présente invention concerne l'utilisation combinée de dérivés acryloyl-distamycine substitués, et en particulier de .alpha.-bromo- et -.alpha.-chloro-acryloyl-distamycine représentés par la formule (I), tels qu'ils sont décrits dans la spécification, d'anti-microtubules, et/ou d'antimétabolites. L'invention concerne également l'utilisation de cette combinaison pour le traitement et/ou la prévention de la métastase, ou pour le traitement de tumeurs par inhibition de l'angiogenèse.
Beria Italo
Cozzi Paolo
Geroni Maria Cristina Rosa
Nerviano Medical Sciences S.r.l.
Pharmacia & Italia S.p.a.
Smart & Biggar
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