Combined therapy against tumors comprising substituted...

Details Combined therapy against tumors comprising substituted... Combined therapy against tumors comprising substituted...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2472008

The present invention provides the combined use of acryloyl distamycin derivatives, in particular .alpha.-bromo- and .alpha.-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and a protein kinase (serine/threonine and tyrosine kinases) inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.

L'invention concerne l'utilisation combinée de dérivés de distamycine d'acryloyle, en particulier les dérivés de distamycine d'alpha-bromo et d'alpha-chloro-acryloyle représentés par la formule (I), tels que spécifiés dans la description, et d'inhibiteurs de protéine kinase (sérine/thréonine et tyrosine kinases), pour le traitement des tumeurs. L'invention concerne également l'utilisation de ce type de combinaison pour le traitement ou la prévention de la métastase ou bien pour le traitement des tumeurs par inhibition de l'angiogenèse.

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