Combined treatment with bortezomib and an epidermal growth...

A - Human Necessities – 61 – K

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A61K 31/69 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2583520

The present invention provides a method for method for manufacturing a medicament intended for treating tumors or tumor metastases in a patient, characterized in that a therapeutically effective amount of an EGFR kinase inhibitor and bortezomib is used, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The invention also encompasses a pharmaceutical composition that is comprised of an EGFR kinase inhibitor and bortezomib combination in a combination with a pharmaceutically acceptable carrier. A preferred example of an EGFR kinase inhibitor that can be used in practicing this invention is the compound erlotinib HCI (also known as Tarceva TM).

L'invention concerne un procédé de fabrication d'un médicament destiné à traiter des tumeurs ou des métastases de tumeur chez un patient, le procédé étant caractérisé par l'utilisation d'une quantité thérapeutiquement efficace d'un inhibiteur des kinases du récepteur du facteur de croissance épidermique (EGFR) et de bortezomib, avec ou sans agents ou traitements complémentaires tels que d'autres anticancéreux ou une radiothérapie. L'invention concerne aussi une composition pharmaceutique comprenant en combinaison un inhibiteur des kinases de l'EGFR et du bortezomib, ainsi qu'un excipient pharmaceutiquement acceptable. Dans un exemple préféré, l'inhibiteur des kinases de l'EGFR utilisé est le composé erlotinib HCl (également appelé Tarceva TM).

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