A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/18 (2006.01) A61K 31/439 (2006.01)
Patent
CA 2741721
The combined use of (R)-5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2- methoxybenzene-1-sulfonamide (tamsulosin), or its pharmaceutically acceptable salt, and (1S)-1-phenyl- 1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid (3R)- quinuclidin-3-yl ester (solifenacin), or its pharmaceutically acceptable salt, for the preparation of a medicament for the improvement of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) with a substantial storage component is provided.
L'invention concerne l'utilisation combinée du composé (R)-5-(2-{[2-(2-éthoxyphénoxy)éthyl]amino}propyl)-2-méthoxybenzène-1-sulfonamide (tamsulosine) ou d'un sel pharmaceutiquement acceptable de ce composé, et du composé (lS)-1-phényl-1,2,3,4-tétrahydroisoquinoline-2-acide carboxylique (3R)-quinuclidin-3-yl ester (solifénacine) ou d'un sel pharmaceutiquement acceptable de ce composé, pour élaborer un médicament destiné à améliorer des symptômes des voies urinaires inférieures associés à une hyperplasie bénigne de la prostate (LUTS/BPH) à l'aide d'un composant de stockage sensible.
Bosman Brigitte Johanna Fanny
Drogendijk Tennis Edwin
Garcia Hernandez Alberto
Klaver Monique Maria Alida
Van Charldorp Karin Juliette
Astellas Ireland Co. Ltd.
Osler Hoskin & Harcourt Llp
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