A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7056 (2006.01) A61K 31/24 (2006.01) A61K 31/282 (2006.01) A61K 31/4745 (2006.01) A61K 31/519 (2006.01) A61K 31/704 (2006.01) A61K 31/7048 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2480335
A combination of pharmaceutical preparations which are simultaneously, separately, or successively administered in treatments for cancers. It comprises the following two separate preparations: * a pharmaceutical preparation comprising a pharmaceutically acceptable support or diluent and either at least one compound represented by the general formula [I]: [I] (wherein R1 and R2 each independently represents hydrogen, lower alkyl, etc.; G represents a pentose group, etc.; and X1 and X2 each independently represents hydrogen, halogeno, etc.) or a pharmaceutically acceptable salt of the compound and * a pharmaceutical preparation comprising a pharmaceutically acceptable support or diluent and any of an anticancer alkylating agent, anticancer antimetabilite, anticancer antibiotic, plant-derived anticancer agent, and the like (the pharmaceutical preparation containing at least one compound represented by the above formula [I] or a pharmaceutically acceptable salt thereof may be used in combination with two or more other anticancer agents). Also provided is a method of treatments for cancers, characterized by administering these pharmaceutical preparations in combination.
L'invention porte sur une combinaison de préparations pharmaceutiques s'administrant simultanément ou successivement dans le traitement du cancer, et qui comporte les constituants suivants: (i) une préparation pharmaceutique comprenant un support ou diluant pharmacocompatible et au moins un composé de formule générale (I) (dans laquelle: R?1¿ et R?2¿ représentent chacun indépendamment hydrogène, alkyl inférieur, etc.; G représente un groupe pentose, etc.; et X?1¿ et X?2¿ représentent chacun indépendamment hydrogène, halogéno, etc.); ou un sel pharmacocompatible dudit composé, et (ii) une préparation pharmaceutique comprenant un support ou diluant pharmacocompatible et un ou plusieurs éléments choisis parmi des agent anticancéreux alkylants, des antimétabolites anticancéreux, des antibiotiques anticancéreux, des dérivés végétaux anticancéreux et autres (ladite préparation pharmaceutique contenenant au moins un composé de la formule (I) ci-dessus ou l'un de ses sels pharmacocompatibles combiné à deux ou plusieurs des agents anticancéreux. L'invention porte également sur une méthode de traitement du cancer caractérisée par l'administration d'une combinaison desdites préparations pharmaceutiques.
Arakawa Hiroharu
Kodera Tsutomu
Monden Yoshiaki
Nakatsuru Yoko
Banyu Pharmaceutical Co. Ltd.
Smart & Biggar
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