Combined use of g-csf and factors having angiogenic action

Details Combined use of g-csf and factors having angiogenic action Combined use of g-csf and factors having angiogenic action

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 35/28 (2006.01) A61K 38/22 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2519412

A remedy efficacious against ischemic diseases which contains, as the active ingredients, granulocyte colony stimulating factor (G-CSF), and hepatocyte growth factor (HGF) or fibroblast growth factor (FGF). Administration of this remedy provides an efficacious therapy of overcoming the faults observed particularly in the existing exercise therapy, drug therapy and revascularization for obstructive arteriosclerosis and gene therapy and intramuscular transplantation of bone marrow cells proposed recently. Moreover, this remedy is also usable as a remedy for ischemic diseases such as ischemic cerebrovascular injury and ischemic heart diseases.

L'invention concerne un remède efficace contre les maladies ischémiques, qui contient, comme principes actifs, le facteur de croissance granulocytaire (G-CSF), et le facteur de croissance hépatocytaire (HGF) ou le facteur de croissance fibroblastique (FGF). L'administration de ce remède permet d'obtenir une thérapie efficace, permettant de supprimer les problèmes observés en particulier dans les thérapies actuelles, la pharmacothérapie et la revascularisation en cas d'artériosclérose obstructive, la thérapie génique et l'implantation intramusculaire de cellules médullaires, proposées récemment. En outre, ce remède peut être utilisé contre les maladies ischémiques telles que l'accident cérébrovasculaire ischémique et les cardiopathies ischémiques.

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