Combined use of genetic markers for the diagnosis of...

Details Combined use of genetic markers for the diagnosis of... Combined use of genetic markers for the diagnosis of...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/11 (2006.01) C07K 14/775 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2184635

Combined use of at least two genetic markers selected from apolipoprotein E, D19S178 and apolipoprotein CII, for the diagnosis of Alzheimer's disease, especially apolipoprotein epsilon 4, long apolipoprotein CII (30+/-3 repeat patterns (CA) and short D19S178 (less than 167+/-4 nucleotides) alleles. The invention also concerns a method for the diagnosis of Alzheimer's disease and a kit for carrying out said method.

L'invention a pour objet l'utilisation conjointe d'au moins deux marqueurs génétiques choisis parmi APOE, D19S178 et APO CII pour le diagnostic de la maladie d'Alzheimer, en particulier les allèles APO e4, APO CII long (30+/-3 motifs répétitifs (CA)) et D19S178 court (moins de 167+/-4 nucléotides). L'invention a également pour objet un procédé de diagnostic de la maladie d'Alzheimer ainsi qu'un kit pour la mise en oeuvre du procédé.

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