Combined use of gnrh agonist and antagonist

Details Combined use of gnrh agonist and antagonist Combined use of gnrh agonist and antagonist

A - Human Necessities

61

K

A61K 38/09 (2006.01)

Patent

CA 2250908

The present invention relates to a pharmaceutical comprising a luteinizing hormone releasing hormone agonist in combination with a luteinizing hormone releasing hormone antagonist. By using a luteinizing hormone releasing hormone agonist and a luteinizing hormone releasing hormone antagonist in combination, the transient exacerbation with elevation of serum testosterone and estrogen owing to the pituitary-gonadotropic action (acute action) manifested immediately following an initial dose of the luteinizing hormone releasing hormone agonist can be successfully obviated.

Cette invention se rapporte à un produit pharmaceutique comprenant un agoniste de l'hormone libératrice de l'hormone lutéotrope en association avec un antagoniste de l'hormone libératrice de l'hormone lutéotrope. En utilisant un agoniste de l'hormone libératrice de l'hormone lutéotrope et un antagoniste de l'hormone libératrice de l'hormone lutéotrope en association, on parvient à empêcher avec succès les poussées passagères avec élévation de la testostérone sérique et des oestrogènes dues à l'action de la gonadotrophine hypophysaire (action aiguë) qui se manifeste immédiatement après la prise d'une dose initiale d'agoniste de l'hormone libératrice de l'hormone lutéotrope.

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