Combined use of n-imidazolyl derivatives of bicyclic...

Details Combined use of n-imidazolyl derivatives of bicyclic... Combined use of n-imidazolyl derivatives of bicyclic...

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2035032

- 21 - ABSTRACT COMBINED USE OF N-IMIDAZOLYL DERIVATIVES OF BICYCLIC COMPOUNDS AND CYCLOSPORIN IN THERAPY The invention relates to the use of N-imidazolyl derivatives of bicyclic compounds of general formula Image (I) wherein a) Image wherein Y completes a single bond or is oxygen or a -CH2- group and the symbol represents a single or double bond or (b) Image is Image and the symbol --- represents a double bond; one of R1, R2, R3 and R4 is -CH2OH, C2-C4 acyl, Image , -COOR7, -CHCOOR7, Image , Image or Image in which each of R7, R8 and R9 is independently hydrogen or C1-C4 alkyl, and the others are independently chosen from hydrogen, hydroxy, halogen, C1-C4 alkyl, C1-C4 alkoxy and -COOR7 wherein R7 is as defined above; and one of R5 and R6 is hydrogen and the other is hydrogen C1-C6 alkyl or phenyl; or a pharmaceutically acceptable salt thereof, in particular in combination with cyclosporin A. The compounds obtained are useful in preventing and/or treating cyclosporin A- induced nephrosis in mammals.

Affiliated with

Also associated with

Rating

Combined use of n-imidazolyl derivatives of bicyclic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Combined use of n-imidazolyl derivatives of bicyclic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combined use of n-imidazolyl derivatives of bicyclic... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1762957