Combined vaccine compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/295 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2324289

Novel combined vaccine compositions preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in addition one or more of the following: an EBV antigen, a hepatitis A antigen or inactivated attenuated virus, an HPV antigen, a VZV antigen, an HCMV antigen, a Toxoplasma gondii antigen. The vaccine compositions are formulated with an adjuvant which is a preferential stimulator of TH1 cell response such as 3D-MPL and QS21.

L'invention concerne de nouvelles compositions de vaccins combinés, destinées de préférence à l'administration aux adolescents et comprenant un antigène viral de l'hépatite B et un antigène viral de l'herpès et éventuellement un ou plusieurs éléments parmi les suivants: un antigène du virus Epstein-Barr, un antigène de l'hépatite A ou un virus atténué inactivé, un antigène de l'HPV, un antigène du virus varicelle-zona, un antigène du virus CMV humain et un antigène de Toxoplasma gondii. Les compositions de vaccin sont préparées avec un adjuvant qui se présente comme un stimulateur préférentiel de la réponse des cellules TH1, par exemple, 3D-MPL et QS21.

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