C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/02 (2006.01) A01N 57/00 (2006.01) A01N 57/26 (2006.01) A61K 31/66 (2006.01) A61K 31/685 (2006.01) C07C 255/43 (2006.01) C07D 213/82 (2006.01) C07D 217/20 (2006.01) C07D 295/027 (2006.01) C07D 453/04 (2006.01) C07F 9/12 (2006.01) C07F 9/22 (2006.01) C07F 9/28 (2006.01)
Patent
CA 2407675
The present invention relates to the syntheses and structural elucidation of Combretastatin A1-Phosphate Prodrugs and Combretastatin B1-Phosphate Prodrugs and the utilization of those prodrugs in the treatment of neoplastic diseases. The prodrugs described herein have the structure: Combretastin A-1 Phosphate Prodrug (I) and Combretastin B-1 Phosphate Prodrug (II).
L'invention concerne des synthèses et des analyses de promédicaments à base de combretastatine A1-phosphate et de promédicaments à base de combretastatine B1-phosphate, et l'utilisation de ces promédicaments pour traiter les maladies néoplasiques. Les promédicaments décrits dans cette invention présentent la structure suivante: (I) promédicament à base de combretastatine A-1 phosphate (II) promédicament à base de combretastatine B-1 phosphate.
Lippert John W. III
Pettit George R.
Acti Ng For And On Behalf Of Arizona State University Arizona Board Of Regents A. Body Corporate Of The State Of Arizo
Borden Ladner Gervais Llp
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