C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/12 (2006.01) A61K 31/66 (2006.01) A61P 35/00 (2006.01) C07C 215/40 (2006.01) C07D 233/64 (2006.01)
Patent
CA 2422359
Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4.
La présente invention se rapporte à de nouveaux sels de promédicaments à base de combrétastatine A-4 qui s'avèrent utiles en ce qu'ils accroissent la solubilité de la combrétastatine A-4, en ce qu'ils régénèrent facilement la combrétastatine A-4 <i>in vivo</i> dans des conditions physiologiques normales et en ce qu'ils produisent des produits physiologiquement tolérables du fait de la régénération de la combrétastatine A-4.
Dahlheim Charles E.
Dali Mandar V.
Dali Manisha M.
Huang Yande
Tejwani Ravindra W.
Bristol-Myers Squibb Company
Smart & Biggar
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