Combretastatin derivatives with cytotoxic action

Details Combretastatin derivatives with cytotoxic action Combretastatin derivatives with cytotoxic action

C - Chemistry, Metallurgy

07

D

C07D 261/12 (2006.01) A61K 31/09 (2006.01) A61K 31/343 (2006.01) A61K 31/41 (2006.01) C07C 43/215 (2006.01) C07C 43/23 (2006.01) C07D 231/56 (2006.01) C07D 261/08 (2006.01) C07D 307/71 (2006.01) C07D 307/79 (2006.01) C07D 333/44 (2006.01) C07D 333/54 (2006.01) C07F 7/18 (2006.01) C07F 9/655 (2006.01) C07F 9/6553 (2006.01)

Patent

CA 2531389

The invention described herein relates to new combretastatin derivatives obtained by total synthesis and having the following general formula (I) in which the groups are as defined in the description here below. Said compounds, though chemically related to the structure of cis/trans-combretastatin, do not always bind tubulin, but nevertheless exhibit cytotoxic activity of interest in the oncological field as anticancer and/or antiangiogenic agents.

L'invention concerne de nouveaux dérivés de la combretastatine que l'on obtient par synthèse totale et qui présente la formule générale suivante, dans laquelle les groupes sont tels que définis dans le descriptif. Lesdits composés, bien que se rapportant au niveau chimique à la structure de la combretastatine cis-trans, ne se lient pas toujours à la tubuline, néanmoins ils présentent une activité cytotoxique intéressante dans le domaine oncologique en tant qu'agents anticancéreux et/ou antiangiogéniques.

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